Challenge 5: Engineer Better Medicines
Textbook of Personalized Medicine by Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain's Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.
Personal Genomics and Personalized Medicine by Current research in genomics and pharmacogenomics is increasingly highlighting the need to move towards stratified disease descriptions and individualized treatment plans. This book explains how a confluence of recent biological, technological and methodological developments is making it possible to provide personalized diagnoses and treatments.By virtue of treating each person's condition as unique, personal genomics and personalized medicine require health professionals to understand the nature of the data, its health implications, and its limitations.This book provides a detailed scientific treatment of the emerging disciplines of personal genomics and personalized medicine. It also includes a comprehensive treatment of both the promises and challenges of personal genomics and medicine from technological, societal and medical perspectives. It offers a wide-ranging review of the state of the art across all aspects of a highly multi-disciplinary subject. This book will be immensely useful for practicing health professionals and researchers, as well as senior undergraduates and graduate students in biomedical sciences.
Genomics and Proteomics Engineering in Medicine and Biology by Current applications and recent advances in genomics and proteomics Genomics and Proteomics Engineering in Medicine and Biology presents a well-rounded, interdisciplinary discussion of a topic that is at the cutting edge of both molecular biology and bioengineering. Compiling contributions by established experts, this book highlights up-to-date applications of biomedical informatics, as well as advancements in genomics-proteomics areas. Structures and algorithms are used to analyze genomic data and develop computational solutions for pathological understanding. Topics discussed include: Qualitative knowledge models Interpreting micro-array data Gene regulation bioinformatics Methods to analyze micro-array Cancer behavior and radiation therapy Error-control codes and the genome Complex life science multi-database queries Computational protein analysis Tumor and tumor suppressor proteins interactionsErwin P. Bottinger, “Foundations, Promises, and Uncertainties of Personalized Medicine,”Mount Sinai Journal of Medicine 74 (2007), pp. 15-21.
Manfred Dietel and Christine Sers, “Personalized medicine and development of targeted therapies: The upcoming challenge for diagnostic molecular pathology. A review,”Virchows Arch 448 (2006), pp. 744-755.
David L. Heymann, “Resistance to Anti-Infective Drugs and the Threat to Public Health,”Cell 124 (February 24, 2006), pp. 671-675. DOI 10.1016/j.cell.2006.02.009.
W. Kalow, “Pharmacogenetics and pharmacogenomics: Origin, status, and the hope for personalized medicine,” The Pharmacogenomics Journal 6 (2006), pp. 162-165. doi:10.1038/sj.tpj.6500361
L.J. Lesko, “Personalized Medicine: Elusive Dream or Imminent Reality?” Clinical Pharmacology & Therapeutics 81 (June 2007), pp. 807-816.
M.P. Lutolf and J.A. Hubbell, “Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering,” Nature Biotechnology 23 (January 2005), pp. 47-55.
Gerard D. Wright and Arlene D. Sutherland, “New strategies for combatingmultidrug-resistant bacteria,” Trends in Molecular Medicine 13 (2007), pp. 260-267. doi:10.1016/j.molmed.2007.04.004.
Mike West et al., “Embracing the complexity of genomic data for personalized medicine,”Genome Research 16 (2006), pp. 559-566.
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